Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol POLR3A contributors: mct/shn - updated : 14-01-2019
HGNC name polymerase (RNA) III (DNA directed) polypeptide A
HGNC id 30074
DNA
TYPE functioning gene
STRUCTURE 54.92 kb     31 Exon(s)
MAPPING cloned Y linked N status provisional
Map cen - D10S206 - D10S569 - POLR3A - D10S607 - D10S1704- qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
31 - 6610 155 1390 - 2018 30450527
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to Polr3a, Mus musculus
ortholog to Polr3a, Rattus norvegicus
ortholog to polr3a, Danio rerio
ortholog to POLR3A, Pan troglodytes
Homologene
FAMILY RNA polymerase beta chain family
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  • has likely critical functions in human development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • plakophilin 2
  • cell & other
    REGULATION
    Other regulated by DNMT1 and DNMT3a
    ASSOCIATED DISORDERS
    corresponding disease(s) HLD7 , NPROS
    Susceptibility to severe Varicella zoster virus (VZV) disease
    Variant & Polymorphism other
  • monogenic or digenic POLR3C deficiencies confer increased susceptibility to severe VZV disease in otherwise healthy children
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS