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FLASH GENE
Symbol CDC42BPA contributors: mct - updated : 05-09-2019
HGNC name CDC42 binding protein kinase alpha (DMPK-like)
HGNC id 1737
Location 1q42.13      Physical location : 227.177.566 - 227.505.826
Synonym name
  • ser-thr protein kinase PK428
  • CDC42 binidng protein kinase beta
  • CDC42-binding protein kinase alpha (DMPK-like)
  • myotonic dystrophy kinase-related CDC42-binding protein kinase alpha
  • ser-thr protein kinase related to the myotonic dystrophy protein kinase
  • Synonym symbol(s) MRCK, MRCKA, PK428, FLJ23347, KIAA0451
    EC.number 2.7.1.37/ 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 328.64 kb     41 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status provisional
    regionally located same location than STK6P, same gene ?
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    36 - 10873 195 1719 - 2016 27025456
    variant B
    35 - 10630 186 1638 - 2016 27025456
  • variant A
  • 36 - 10820 - 1699 - 2016 27025456
    variant E
    35 - 10789 - 1691 - 2016 27025456
    variant D
    36 - 10912 - 17312 - 2016 27025456
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
    Reproductivemale systemtestis  highly Homo sapiens
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal moderately Homo sapiens
    cell lineage
    cell lines various cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal domain
  • highly similar to the kinase kinase domain of DMPK followed by a predicted helical domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Pk428
    Homologene
    FAMILY Ser/Thr protein kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • protein serine/threonine kinase activity
  • possible role in the transferrin iron uptake pathway
  • serine/threonine kinase that can regulate actin/myosin assembly and activity
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • signaling cascade that involves FAM89B-CDC42BPA and LIMK1-cofilin in the regulation of lamellipodial F-actin dynamics important for cell protrusion and migration
  • a component
  • CDC42BPA and MYO18A linked by the adaptor protein LURAP1 form a functional tripartite complex, which is responsible for the assembly of lamellar actomyosin bundles and of a subnuclear actomyosin network
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
  • PDK1 positively modulates CDC42BPAactivity and drives its localization within lamellipodia
  • lamellipodium-localized FAM89B-CDC42BPA complex is essential for the regulation of local LIMK1 and its downstream F-actin regulatory factor cofilin
  • FAM89B interacts with CDC42BPA through the conserved LR motif
  • cell & other
    REGULATION
    activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion
    Other regulated by iron levels
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    CCND1/CDC42BPA gene fusion in mantle cell lymphoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS