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FLASH GENE

Symbol

FOXO1

contributors: mct - updated : 17-08-2020

HGNC name	forkhead box O1
HGNC id	3819

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	FoxO1-deficient embryos manifest progressive apoptotic cell death
	mice lacking FOXO1 in steroidogenic factor 1 (NR5A1) neurons of the ventromedial hypothalamus are lean due to increased energy expenditure
	mice with Treg-cell-specific deletion of Foxo1 develop a fatal inflammatory disorder similar in severity to that seen in Foxp3-deficient mice, but without the loss of Treg cells