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FLASH GENE
Symbol CHST11 contributors: mct - updated : 28-08-2015
HGNC name carbohydrate (chondroitin 4) sulfotransferase 11
HGNC id 17422
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two functional intronic PPARG binding sites
  • four potential sites for N-glycosylation
  • a C terminal catalytic domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine C4st
    homolog to Drosophila CG4826
    intraspecies homolog to C4ST2
    Homologene
    FAMILY
  • sulfotransferase 2 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane protein
    basic FUNCTION
  • the synthesis of dermatan and chondroitin sulfate, transfering sulfate to the C4 position of N-acetylgalactosamine
  • chondroitin 4-O-sulfation by CHST11 is required for proper chondroitin sulfate localization, modulation of distinct signaling pathways and cartilage growth plate morphogenesis
  • Golgi-bound enzyme involved in the biosynthesis of the glycosaminoglycan chondroitin sulfate
  • is a key downstream target of WNT signaling that regulates WNT diffusion from WNT-producing cells
  • can sulphate chondroitin, a major glycosaminoglycan involved in development and disease
  • may play a direct role in progression of breast cancer and its expression is controlled by DNA methylation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    proteoglycan
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a negatively regulated target gene of HRAS signaling
  • CHST11 is a novel PPARG target gene
  • TWIST1-binding sequences associated with CHST11, LITAF, ROR2, and SPATA5 also bound the potential TWIST1 cofactor RREB1
    • cell & other
    REGULATION
    Other regulation of CHST11 expression by opposing effects of arylsulfatase B on BMP4 and WNT9A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal carcinomas
    tumoral     --over  
    highly expressed in breast cancer tissues compared to normal tissues and the expression levels were significantly associated with tumor progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CHST11 is independent unfavorable prognostic factor in ovarian cancer
    • Therapy target
    ANIMAL & CELL MODELS
  • mouse C4st-1 as a target gene of ligands of the TGFbeta superfamily of growth factors, which could positively regulate C4st-1 expression in a number of cell types