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FLASH GENE

Symbol

CHST11

contributors: mct - updated : 28-08-2015

HGNC name	carbohydrate (chondroitin 4) sulfotransferase 11
HGNC id	17422

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q23.3      Physical location : 104.850.691 - 105.155.783
Synonym name	chondroitin 4-sulfotransferase
	chondroitin 4-O-sulfotransferase 1
Synonym symbol(s)	C4ST1, C4ST, HSA269537
EC.number	2.8.2.5

DNA

TYPE	functioning gene
STRUCTURE	305.10 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018413 3 - 5768 NP_060883 41.4 352 - 2012 22317973 NM_001173982 3 - 5753 NP_001167453 - 347 - 2012 22317973

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen           thymus       highly Nervous brain         Reproductive male system prostate       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two functional intronic PPARG binding sites
	four potential sites for N-glycosylation
	a C terminal catalytic domain

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine C4st
	homolog to Drosophila CG4826

intraspecies

homolog to C4ST2

Homologene

FAMILY

sulfotransferase 2 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type II transmembrane protein

basic FUNCTION	the synthesis of dermatan and chondroitin sulfate, transfering sulfate to the C4 position of N-acetylgalactosamine
	chondroitin 4-O-sulfation by CHST11 is required for proper chondroitin sulfate localization, modulation of distinct signaling pathways and cartilage growth plate morphogenesis
	Golgi-bound enzyme involved in the biosynthesis of the glycosaminoglycan chondroitin sulfate
	is a key downstream target of WNT signaling that regulates WNT diffusion from WNT-producing cells
	can sulphate chondroitin, a major glycosaminoglycan involved in development and disease
	may play a direct role in progression of breast cancer and its expression is controlled by DNA methylation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

proteoglycan

a component

INTERACTION

DNA

RNA

small molecule

protein	is a negatively regulated target gene of HRAS signaling
	CHST11 is a novel PPARG target gene
	TWIST1-binding sequences associated with CHST11, LITAF, ROR2, and SPATA5 also bound the potential TWIST1 cofactor RREB1

cell & other

REGULATION

Other

regulation of CHST11 expression by opposing effects of arylsulfatase B on BMP4 and WNT9A

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colorectal carcinomas tumoral     --over   highly expressed in breast cancer tissues compared to normal tissues and the expression levels were significantly associated with tumor progression

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	CHST11 is independent unfavorable prognostic factor in ovarian cancer
Therapy target

ANIMAL & CELL MODELS

mouse C4st-1 as a target gene of ligands of the TGFbeta superfamily of growth factors, which could positively regulate C4st-1 expression in a number of cell types