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FLASH GENE
Symbol CHST6 contributors: mct - updated : 05-03-2007
HGNC name carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
HGNC id 6938
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer dimer
HOMOLOGY
interspecies homolog to Drosophila CG3267
homolog to C.elegans F02A9.4a
Homologene
FAMILY
  • sulfotransferase family
  • Gal/GlcNAc/GalNAc subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II transmembrane protein
    basic FUNCTION
  • production of sulfated keratan
  • mediating sulfation of keratan in cornea (keratan sulfate plays a central role in maintaining
    • corneal transparency)
    CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text necessary for maintening transparency of cornea
    PATHWAY
    metabolism carbohydrate
    signaling sensory transduction/vision
    polysaccharides
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    binds 2 zinc ions per subunit
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCDC1
    Susceptibility to Parkinson disease
    Variant & Polymorphism SNP increasing the risk of Parkinson disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS