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FLASH GENE
Symbol CHST6 contributors: mct - updated : 05-03-2007
HGNC name carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
HGNC id 6938
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselscapillary   
Digestiveintestinesmall intestine  highly
Nervousspinal cord    
Reproductivemale systemprostate  highly
Respiratorylung   highly
Visualeyeanterior segmentcornea  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Epithelialbarrier/liningcorneal epithelium  
Epithelialbarrier/liningcorneal stroma  
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer dimer
HOMOLOGY
interspecies homolog to Drosophila CG3267
homolog to C.elegans F02A9.4a
Homologene
FAMILY
  • sulfotransferase family
  • Gal/GlcNAc/GalNAc subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II transmembrane protein
    basic FUNCTION
  • production of sulfated keratan
  • mediating sulfation of keratan in cornea (keratan sulfate plays a central role in maintaining
    • corneal transparency)
    CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text necessary for maintening transparency of cornea
    PATHWAY
    metabolism carbohydrate
    signaling sensory transduction/vision
    polysaccharides
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    binds 2 zinc ions per subunit
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCDC1
    Susceptibility to Parkinson disease
    Variant & Polymorphism SNP increasing the risk of Parkinson disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS