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FLASH GENE
Symbol CHST6 contributors: mct - updated : 05-03-2007
HGNC name carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
HGNC id 6938
Corresponding disease
MCDC1 macular dystrophy, corneal 1
Location 16q22      Physical location : 75.507.022 - 75.528.926
Synonym name
  • corneal N-acetylglucosamine 6-sulfotransferase
  • carbohydate sulfotransferase 6
  • N-acetylglucosamine 6-O- sulfotransferase 5
  • corneal N-acetylglucosamine 6-sulfotransferase
    • Synonym symbol(s) MCDC1
    DNA
    TYPE functioning gene
    STRUCTURE 21.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    regionally located 30 kDa downstream CHST5
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselscapillary   
    Digestiveintestinesmall intestine  highly
    Nervousspinal cord    
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Visualeyeanterior segmentcornea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Epithelialbarrier/liningcorneal epithelium  
    Epithelialbarrier/liningcorneal stroma  
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer dimer
    HOMOLOGY
    interspecies homolog to Drosophila CG3267
    homolog to C.elegans F02A9.4a
    Homologene
    FAMILY
  • sulfotransferase family
  • Gal/GlcNAc/GalNAc subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II transmembrane protein
    basic FUNCTION
  • production of sulfated keratan
  • mediating sulfation of keratan in cornea (keratan sulfate plays a central role in maintaining
    • corneal transparency)
    CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text necessary for maintening transparency of cornea
    PATHWAY
    metabolism carbohydrate
    signaling sensory transduction/vision
    polysaccharides
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    binds 2 zinc ions per subunit
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCDC1
    Susceptibility to Parkinson disease
    Variant & Polymorphism SNP increasing the risk of Parkinson disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS