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FLASH GENE
Symbol ARIH1 contributors: mct - updated : 20-10-2013
HGNC name ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)
HGNC id 689
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • N-terminal canonical RING1 has been shown to be the principal E2-binding region, although RING2 is also required for ligase activity
  • a highly acidic domain
  • a poly (gly) tract in the N terminus
  • two RING fingers and an IBR domains between RING fingers in the central region, with a RING2 from the RING-IBR-RING motif having a completely distinct topology from classical RINGs
    • HOMOLOGY
    interspecies ortholog to ariadne Drosophila
    homolog to murine Arih1
    Homologene
    FAMILY Ariadne subfamily ligases
    CATEGORY enzyme , unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing a role of an E3 ubiquitin-protein ligase
  • ARIH1 and PARK2 functioning via a HECT-like mechanism whereby RING1 harbours the E2-binding site and RING2 harbours the active-site cysteine
    • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • UBE2G2 (E2-UbcH7) through the RING1 finger domain
  • E2-UBCH8
  • interacts and co-localizes with UBE2L3 in mammalian cells, particularly in the perinuclear region
  • ARIH1, ARIH2 bind to and are activated by distinct neddylated Cullin-RING ligase complexes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS