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FLASH GENE

Symbol

ARIH1

contributors: mct - updated : 20-10-2013

HGNC name	ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)
HGNC id	689

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q24.1      Physical location : 72.766.666 - 72.878.895
Synonym symbol(s)	HAR, HHARI, UBCH7BP, ARI, HARI, MOP-6, H7-AP2

DNA

TYPE	functioning gene
STRUCTURE	112.23 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed - - - 2200 - - weakly expressed except in testis where it was predominant 1999 10521492 - - - 2700 - - - 1999 10521492 NM_005744 14 - 5267 - 557 - 2001 11278816

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Respiratory lung       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Muscular striatum cardiac     Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains	N-terminal canonical RING1 has been shown to be the principal E2-binding region, although RING2 is also required for ligase activity
	a highly acidic domain
	a poly (gly) tract in the N terminus
	two RING fingers and an IBR domains between RING fingers in the central region, with a RING2 from the RING-IBR-RING motif having a completely distinct topology from classical RINGs

HOMOLOGY

interspecies	ortholog to ariadne Drosophila
	homolog to murine Arih1

Homologene

FAMILY

Ariadne subfamily ligases

CATEGORY

enzyme , unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	playing a role of an E3 ubiquitin-protein ligase
	ARIH1 and PARK2 functioning via a HECT-like mechanism whereby RING1 harbours the E2-binding site and RING2 harbours the active-site cysteine

CELLULAR PROCESS	protein, degradation
	protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	zinc Zn2+

protein	UBE2G2 (E2-UbcH7) through the RING1 finger domain
	E2-UBCH8
	interacts and co-localizes with UBE2L3 in mammalian cells, particularly in the perinuclear region
	ARIH1, ARIH2 bind to and are activated by distinct neddylated Cullin-RING ligase complexes

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS